附件99.1

Akari Treateutics和Peak Bio宣佈達成最終協議,將平等合併,創建一條擴展的管道
一個新的抗體藥物結合物(ADC)工具包

馬薩諸塞州波士頓和加利福尼亞州PLEASANTON-2024年3月5日(環球通訊社)-阿卡里治療公司(納斯達克:AKTX),一家開發自身免疫和炎症性疾病先進療法的晚期生物技術公司,與匹克生物公司(場外交易代碼:PKBO),一家專注於開發炎症和腫瘤學領域治療藥物的臨牀階段生物製藥公司,宣佈了一項最終協議,將在全股票交易中平等合併。合併後的實體將以阿卡里治療公司的名稱運營,預計該公司將繼續以AKTX的名稱在納斯達克資本市場上市和交易。

完成交易後, 公司將擁有一個擴展的渠道,其中包含跨越早期和後期開發階段的多個引人注目的資產。 計劃對渠道進行評估,包括計劃優先順序、更新的時間表、短期價值創造機會和其他考慮因素。合併的主要亮點包括:

匹克的創新ADC工具包和領先計劃

·合併後的管道具有強大的ADC工具包,具有新的有效負載和鏈接器技術。通過將化療與免疫治療策略相結合,合併後的公司旨在為癌症患者開發尖端解決方案。此外,該計劃還包括一種新的針對trop-2的臨牀前ADC候選藥物。

跨越早期和後期的多種引人注目的資產

·Akari公司的諾馬可潘是補體C5和白三烯B4(LTB4)的雙特異性重組抑制劑,正在進行兒童造血幹細胞移植相關血栓性微血管病(HSCT-TMA)的3期臨牀試驗。它有可能成為首個被批准的治療HSCT-TMA的方法,HSCT-TMA是幹細胞移植的一種罕見併發症,在重症成人和兒童患者中死亡率高達80%。

·Akari的長效諾馬可潘(PASylated-Nomacopan)正處於治療地理萎縮(GA)的臨牀前開發的最後階段。它有可能解決患者尚未滿足的重大需求 包括玻璃體內注射之間的更長劑量間隔和降低脈絡膜新生血管(CNV)風險,這與目前GA治療中已批准的僅限補體抑制劑有關。

·匹克生物公司的第二階段就緒PHP-303計劃針對的是阿爾法-1抗胰蛋白酶 缺乏(AATD)。該計劃獲得了拜耳醫療保健公司的許可,是5這是生成針對AATD炎症方面的中性粒細胞彈性蛋白酶抑制物(NEI),這是一種罕見的情況。

戰略重點

·合併後的公司預計將強調業務開發和許可 ,對患者具有廣泛的潛在影響。

成熟的領導力

·領導力具有豐富的戰略和運營經驗。HoYoung Huh,醫學博士,博士預計將擔任合併後實體的即將上任的董事會主席。許博士目前是柔韌治療公司的董事會主席和BridgeBio Pharma的聯合創始人。他是Geron Corporation、CytomX Treateutics、Epichyme的前董事長,也是麥肯錫公司的前合夥人。

合併後的董事會將 由每家公司選出的三名董事和一名獨立的董事共同選出。

交易細節

根據協議條款,匹克股東每持有匹克股票 股,將獲得一定數量的阿卡里普通股(以美國存托股份為代表),這是根據協議中描述的交換比例確定的。預計此次交換將在完全稀釋的基礎上,使Akari股東和Peak股東在合併後的公司中分別擁有約50%和約50%的隱含股權,在某些情況下可能會進行調整,包括基於雙方在擬議交易完成時的相對淨現金水平。

您可以免費獲得S-4表格中的註冊聲明、聯合委託書/招股説明書和其他相關文件(如果可以獲得),這些文件是 或將免費提交給美國證券交易委員會的,網址為www.sec.gov。阿卡利提交給美國證券交易委員會的文件的副本將在阿卡里的網站http://investor.akaritx.com/上免費獲取,或聯繫阿卡里的投資者關係部 http://investor.akaritx.com/investor-resources/contact-us.。匹克生物提交給美國證券交易委員會的文件副本將 在匹克生物的網站https://peak-bio.com/investors上免費提供,或聯繫匹克生物的投資者關係部 https://peak-bio.com/contact.。

徵集活動的參與者

Akari、匹克生物及其各自的董事和高管以及管理層和員工的其他成員可被視為就擬議交易徵集 委託書的參與者。有關AKARI董事和高管的信息,包括對他們直接或間接利益的描述,包括對他們通過持有證券或其他方式的直接或間接利益的描述,已在2023年5月1日提交給美國證券交易委員會的AKARI截至2022年12月31日的20-F年度報告、隨後分別以FORM 10-Q 和-K表格提交的季度報告和當前報告中闡述,以及可能不時提交給美國證券交易委員會的其他文件。匹克生物董事和高管的信息,包括對其直接或間接利益的描述,包括所持證券或其他方式的描述,載於匹克生物2022年10月19日提交給美國證券交易委員會的2022年股東特別大會委託書、2023年6月29日提交給美國證券交易委員會的截至2022年12月31日的截至2022年12月31日的10-K表格年度報告、隨後分別提交給美國證券交易委員會的10-Q表格和8-K表格的後續季度報告和當前報告,以及可能不時提交給美國證券交易委員會的其他文件。有關委託書徵集參與人的其他信息,以及對他們直接和間接利益的描述, 通過證券持有或其他方式,將包含在 S-4表格登記説明書中的聯合委託書/招股説明書中,以及在獲得此類材料後提交給美國證券交易委員會的有關擬議交易的其他相關材料。 證券持有人、潛在投資者和其他讀者在做出任何投票或投資決定之前,應仔細閲讀S-4表格登記 説明書中包含的聯合委託書/招股説明書。您可以使用上述來源從Akari或Peak Bio獲得這些文檔的免費副本 。

瞭解更多信息

投資者聯繫方式:

Mike·莫耶

生活科學顧問

郵箱:mmoyer@lifescivisors.com

媒體聯繫人:

伊萊扎·施萊夫斯坦

施萊夫斯坦公關

郵箱:eliza@schleifsteinpr.com

Cautionary Note Regarding Forward-Looking Statements

This communication relates to the proposed transaction pursuant to the terms of the Merger Agreement, by and among Akari, Pegasus Merger Sub, Inc., and Peak Bio. This communication includes express or implied forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), about the proposed transaction between Peak Bio and Akari and the operations of the combined company that involve risks and uncertainties relating to future events and the future performance of Akari and Peak Bio. Actual events or results may differ materially from these forward-looking statements. Words such as “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “estimate,” “predict,” “project,” “potential,” “continue,” “future,” “opportunity” “will likely result,” “target,” variations of such words, and similar expressions or negatives of these words are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. Examples of such forward-looking statements include, but are not limited to, express or implied statements regarding: the business combination and related matters, including, but not limited to, satisfaction of closing conditions to the proposed transaction, prospective performance and opportunities with respect to Akari or Peak Bio, post-closing operations and the outlook for the companies’ businesses; Akari’s, Peak Bio’s or the combined company’s targets, plans, objectives or goals for future operations, including those related to Akari’s and Peak Bio’s product candidates, research and development, product candidate introductions and product candidate approvals as well as cooperation in relation thereto; projections of or targets for revenues, costs, income (or loss), earnings per share, capital expenditures, dividends, capital structure, net financials and other financial measures; future economic performance, future actions and outcome of contingencies such as legal proceedings; and the assumptions underlying or relating to such statements.

These statements are based on Akari’s and Peak Bio’s current plans, estimates and projections. By their very nature, forward-looking statements involve inherent risks and uncertainties, both general and specific. A number of important factors, including those described in this communication, could cause actual results to differ materially from those contemplated in any forward-looking statements. Factors that may affect future results and may cause these forward-looking statements to be inaccurate include, without limitation: uncertainties as to the timing for completion of the proposed transaction; uncertainties as to Peak Bio’s and/or Akari’s ability to obtain the approval of Akari’s shareholders or Peak Bio’s stockholders required to consummate the proposed transaction; the possibility that competing offers will be made by third parties; the occurrence of events that may give rise to a right of one or both of Akari and Peak Bio to terminate the merger agreement; the possibility that various closing conditions for the proposed transaction may not be satisfied or waived on a timely basis or at all, including the possibility that a governmental entity may prohibit, delay, or refuse to grant approval, if required, for the consummation of the proposed transaction (or only grant approval subject to adverse conditions or limitations); the difficulty of predicting the timing or outcome of consents or regulatory approvals or actions, if any; the possibility that the proposed transaction may not be completed in the time frame expected by Akari and Peak Bio, or at all; the risk that Akari and Peak Bio may not realize the anticipated benefits of the proposed transaction in the time frame expected, or at all; the effects of the proposed transaction on relationships with Akari’s or Peak Bio’s employees, business or collaboration partners or governmental entities; the ability to retain and hire key personnel; potential adverse reactions or changes to business relationships resulting from the announcement or completion of the proposed transaction; significant or unexpected costs, charges or expenses resulting from the proposed transaction; the potential impact of unforeseen liabilities, future capital expenditures, revenues, costs, expenses, earnings, synergies, economic performance, indebtedness, financial condition and losses on the future prospects, business and management strategies for the management, expansion and growth of the combined business after the consummation of the proposed transaction; potential negative effects related to this announcement or the consummation of the proposed transaction on the market price of Akari’s American Depositary Shares or Peak Bio’s common stock and/or Akari’s or Peak Bio’s operating or financial results; uncertainties as to the long-term value of Akari’s American Depositary Shares (and the ordinary shares represented thereby), including the dilution caused by Akari’s issuance of additional American Depositary Shares (and the ordinary shares represented thereby) in connection with the proposed transaction; unknown liabilities related to Akari or Peak Bio; the nature, cost and outcome of any litigation and other legal proceedings involving Akari, Peak Bio or their respective directors, including any legal proceedings related to the proposed transaction; risks related to global as well as local political and economic conditions, including interest rate and currency exchange rate fluctuations; potential delays or failures related to research and/or development of Akari’s or Peak Bio’s programs or product candidates; risks related to any loss of Akari’s or Peak Bio’s patents or other intellectual property rights; any interruptions of the supply chain for raw materials or manufacturing for Akari or Peak Bio’s product candidates, the nature, timing, cost and possible success and therapeutic applications of product candidates being developed by Akari, Peak Bio and/or their respective collaborators or licensees; the extent to which the results from the research and development programs conducted by Akari, Peak Bio, and/or their respective collaborators or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; uncertainty of the utilization, market acceptance, and commercial success of Akari’s or Peak Bio’s product candidates, and the impact of studies (whether conducted by Akari, Peak Bio or others and whether mandated or voluntary) on any of the foregoing; unexpected breaches or terminations with respect to Akari’s or Peak Bios’s material contracts or arrangements; risks related to competition for Akari’s or Peak Bio’s product candidates; Akari’s or Peak Bio’s ability to successfully develop or commercialize Akari’s or Peak Bio’s product candidates; Akari’s, Peak Bio’s, and their collaborators’ abilities to continue to conduct current and future developmental, preclinical and clinical programs; potential exposure to legal proceedings and investigations; risks related to changes in governmental laws and related interpretation thereof, including on reimbursement, intellectual property protection and regulatory controls on testing, approval, manufacturing, development or commercialization of any of Akari’s or Peak Bio’s product candidates; unexpected increase in costs and expenses with respect to the potential transaction or Akari’s or Peak Bio’s business or operations; and risks and uncertainties related to epidemics, pandemics or other public health crises and their impact on Akari’s and Peak Bio’s respective businesses, operations, supply chain, patient enrollment and retention, preclinical and clinical trials, strategy, goals and anticipated milestones. While the foregoing list of factors presented here is considered representative, no list should be considered to be a complete statement of all potential risks and uncertainties. There can be no assurance that the proposed transaction or any other transaction described above will in fact be consummated in the manner described or at all. A more complete description of these and other material risks can be found in Akari’s and Peak Bios’s respective filings with the U.S. Securities and Exchange Commission (the “SEC”), including each of their Annual Reports on Form 20-F and 10-K, respectively, for the year ended December 31, 2022, subsequent periodic reports, and other documents that may be filed from time to time with the SEC. These risks, as well as other risks associated with the proposed transaction, will be more fully discussed in the joint proxy statement/prospectus that will be included in the registration statement on Form S-4 that will be filed with the SEC in connection with the proposed transaction, which joint proxy statement/prospectus will be mailed or otherwise disseminated to Akari’s shareholders and Peak Bio’s stockholders when it becomes available.

Any forward-looking statements speak only as of the date of this communication and are made based on the current beliefs and judgments of Akari’s and Peak Bio’s management, and the reader is cautioned not to rely on any forward-looking statements made by Akari or Peak Bio. Unless required by law, neither Akari nor Peak Bio is under no duty and undertakes no obligation to update or revise any forward-looking statement after the distribution of this document, including without limitation any financial projection or guidance, whether as a result of new information, future events or otherwise.

No Offer or Solicitation

This communication is not intended to and shall not constitute an offer to subscribe for, buy or sell or the solicitation of an offer to subscribe for, buy or sell any securities, or a solicitation of any vote or approval, nor shall there be any sale of, or offer to sell or buy, securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. This communication is for informational purposes only. No offering of securities shall be made, except by means of a prospectus meeting the requirements of Section 10 of the U.S. Securities Act of 1933, as amended, and otherwise in accordance with applicable law.

Additional Information and Where to Find It

In connection with the proposed transaction, Akari and Peak Bio expect to file with the SEC a Registration Statement on Form S-4. The Registration Statement on Form S-4 will include a prospectus of Akari and a joint proxy statement of Akari and Peak Bio, and each party may also file other documents regarding the proposed transaction with the SEC. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ CAREFULLY THE REGISTRATION STATEMENT ON FORM S-4, JOINT PROXY STATEMENT/PROSPECTUS AND OTHER RELEVANT DOCUMENTS FILED OR WILL BE FILED WITH THE SEC, AS WELL AS ANY AMENDMENTS OR SUPPLEMENTS THERETO AND ANY DOCUMENTS INCORPORATED BY REFERENCE THEREIN, IN THEIR ENTIRETY IF AND WHEN THEY BECOME AVAILABLE BECAUSE THEY CONTAIN OR WILL CONTAIN IMPORTANT INFORMATION ABOUT THE PROPOSED TRANSACTION, RELATED MATTERS AND THE PARTIES TO THE PROPOSED TRANSACTION.

You may obtain a free copy of the Registration Statement on Form S-4, joint proxy statement/prospectus and other relevant documents (if and when they become available) that are or will be filed with the SEC for free at the SEC’s website at www.sec.gov. Copies of the documents filed with the SEC by Akari will be available free of charge on Akari’s website at http://investor.akaritx.com/ or by contacting Akari’s Investor Relations Department at http://investor.akaritx.com/investor-resources/contact-us. Copies of the documents filed with the SEC by Peak Bio will be available free of charge on Peak Bio’s website at https://peak-bio.com/investors or by contacting Peak Bio’s Investor Relations Department at https://peak-bio.com/contact.

Participants in the Solicitation

Akari, Peak Bio and their respective directors and executive officers and other members of management and employees may be deemed to be participants in the solicitation of proxies in respect of the proposed transaction. Information about the directors and executive officers of Akari, including a description of their direct or indirect interests, by security holdings or otherwise, is set forth in Akari’s Annual Report on Form 20-F for the year ended December 31, 2022 filed with the SEC on May 1, 2023, subsequent quarterly and current reports on Form 10-Q and -K, respectively, and other documents that may be filed from time to time with the SEC. Information about the directors and executive officers of Peak Bio, including a description of their direct or indirect interests, by security holdings or otherwise, is set forth in Peak Bio’s proxy statement for its 2022 Special Meeting of Stockholders, which was filed with the SEC on October 19, 2022, the Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on June 29, 2023, subsequent quarterly and current reports on Form 10-Q and Form 8-K, respectively, and other documents that may be filed from time to time with the SEC. Other information regarding the participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, will be contained in the joint proxy statement/prospectus included in the Registration Statement on Form S-4 and other relevant materials to be filed with the SEC regarding the proposed transaction when such materials become available. Security holders, potential investors and other readers should read the joint proxy statement/prospectus, included in the Registration Statement on Form S-4 carefully when it becomes available before making any voting or investment decision. You may obtain free copies of these documents from Akari or Peak Bio using the sources indicated above.

For more information

Investor Contact:
Mike Moyer
LifeSci Advisors
(617) 308-4306
mmoyer@lifesciadvisors.com

Media Contact:

Eliza Schleifstein
Schleifstein PR
(917) 763-8106
eliza@schleifsteinpr.com