根據不列顛哥倫比亞省法律註冊成立的公司在上述公司的法定股份結構中的若干定義與此相反，但須受本公司章程的規限，該公司章程細則可由登記持有人本人或交回本證書後以書面正式授權的受權人轉讓至本公司的中央證券登記冊。本證書除非由本公司的轉讓代理及註冊處處長加簽，否則無效。該等股份附有特別權利及限制，其全文可應要求免費向本公司註冊辦事處或檔案處索取。茲證明，公司已安排由其正式授權的高級職員在温哥華的傳真簽名，代表公司簽署本證書。, 不列顛哥倫比亞省。C0000000230|M**SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORK S*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W1020000 0000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN9 8985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.ZERO*SPECIMEN98985W102000000ZYMEWOR KS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W102000 00000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN 98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWO RKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200 000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIMEN98985W10200000000ZYMEWORKS*INC.zero****SPECIME Specii en**098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W 10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W102000000 00ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWOR KS*INC.zero****098985W10200000000ZYMEWORKS*INC.ze ro****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098 985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200 000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYM EWORKS*INC.zero****098985W10200000000ZYMEWORKS*IN C.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W10200000000ZYMEWORKS*INC.zero****098985W1*0**1月28日, 2022年00000000股數字股份股本中沒有面值的繳足股款和不可評估普通股是本證書的註冊持有人，日期為：本證書所代表的股份可在ComputerShare Investor Services Inc.位於不列顛哥倫比亞省温哥華和多倫多的辦事處，或在ComputerShare Trust Company，N.A.位於馬薩諸塞州坎頓、新澤西州澤西城和肯塔基州路易斯維爾的辦事處轉讓。Zymeworks Inc.會籤並註冊Computershare Trust Company，N.A.(馬薩諸塞州坎頓、新澤西州澤西城和肯塔基州路易斯維爾)轉讓代理和註冊商會籤並註冊ComputerShare投資者服務公司。_總裁兼首席執行官首席運營官兼首席財務官*0*0*0**0*CUSIP 98985W102 ISIN CA98985W1023 Zymeworks Inc.C SA E_W IP_Y Z M Q_C 01.mtl.Pulls/000001/000001/i