12 对 29 名
耐药性抑郁患者进行双盲、随机安慰剂对照试验 DMT 临床证据:DMT 在 TRD 中的随机对照试验的疗效先前的临床证据(第三方 STUDY1)双盲、随机安慰剂对照试验 Ayahuasca(DMT 是主要活性成分)
对 29 名患者 TRD 安慰剂 N, N-DMT P<.0001 score trd="Treatment" resistant depression dmt="N,N-Dimethyltryptamine 1." palhano-fontes et al. antidepressant e of the psychedelic ayahuasca in treatment-resistant psychol med a single administration .36 mg met both primary and key secondary efficacy endpoints by demonstrating rapid statistically significant changes on severity measures ham-d madrs endpoint not shown n arm achieved difference relative to placebo were no serious adverse events reported. see left differences observed at all timepoints assessed including as early day through is potential registrational endpoint. takeaways>