通过埃德加

2017年月一日

美国证券交易委员会

公司财务部

东经F街100号

华盛顿特区20549

表格上登记声明的加速请求S-3

文件编号333-221491

女士们先生们：

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), CRISPR Therapeutics AG (the “Company”) hereby requests that the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated to December 4, 2017, at 4:01 pm Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Goodwin Procter LLP, request by telephone that such Registration Statement be declared effective at some other time.在提出这一加速请求时，该公司承认它知道它根据该法案所承担的责任。

如果您对此请求有任何疑问，请与Goodwin Procter LLP公司的Robert Puopolo联系，电话：(617) 570-1393.